3′-Azido-2′,3′-dideoxy-GTP (AZddGTP) is a selective inhibitor of telomerase, exhibiting a Ki value of 1.5 μM. This compound can be incorporated into the 3′-terminus of DNA by telomerase, leading to the inhibition of telomerase activity. Research applications include studying telomerase function and its role in cellular aging and cancer biology, particularly in HeLa cells in vitro.
3′-Azido-2′,3′-dideoxy-GTP (AZddGTP) is a selective inhibitor of telomerase, exhibiting a Ki value of 1.5 μM. This compound can be incorporated into the 3′-terminus of DNA by telomerase, leading to the inhibition of telomerase activity. Research applications include studying telomerase function and its role in cellular aging and cancer biology, particularly in HeLa cells in vitro.
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