(3S,4S)-PF-06459988 is a selective irreversible inhibitor targeting the T790M mutant form of the epidermal growth factor receptor (EGFR). This compound demonstrates significant biological activity against mutant EGFR while exhibiting excellent selectivity for the wild-type receptor. Its design features a minimally reactive electrophile, which reduces the likelihood of off-target labeling, making it a valuable reagent for cancer research and studies investigating EGFR-driven pathways.
(3S,4S)-PF-06459988 is a selective irreversible inhibitor targeting the T790M mutant form of the epidermal growth factor receptor (EGFR). This compound demonstrates significant biological activity against mutant EGFR while exhibiting excellent selectivity for the wild-type receptor. Its design features a minimally reactive electrophile, which reduces the likelihood of off-target labeling, making it a valuable reagent for cancer research and studies investigating EGFR-driven pathways.
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