4-trans-Hydroxy-glibenclamide is a potent inhibitor of the SUR1/Kir6.2 potassium channels. As an active metabolite of the sulfonylurea inhibitor glyburide, it effectively disrupts glyburide binding to rat brain synaptosomes, exhibiting IC50 values of 0.95 nM and 100 nM at high and low affinity sites, respectively. This compound is valuable for research applications focused on investigating the physiological and pharmacological roles of potassium channels in cellular processes and metabolic disorders.
4-trans-Hydroxy-glibenclamide is a potent inhibitor of the SUR1/Kir6.2 potassium channels. As an active metabolite of the sulfonylurea inhibitor glyburide, it effectively disrupts glyburide binding to rat brain synaptosomes, exhibiting IC50 values of 0.95 nM and 100 nM at high and low affinity sites, respectively. This compound is valuable for research applications focused on investigating the physiological and pharmacological roles of potassium channels in cellular processes and metabolic disorders.
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