(4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3

Catalog No.: A80317
E3 ligase ligand-Linker Conjugate
(4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 is an E3 ligase ligand-linker conjugate that features the (4R,5S)-Nutlin carboxylic acid component, which targets MDM2. This compound enables the design of PROTACs by linking to a target protein, facilitating targeted protein degradation. It is particularly useful in research applications focused on modulating EZH2 levels and investigating E3 ligase functionalities in cellular systems.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
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Nature volume 574, pages268-272 (2019)
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Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
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Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(4R,5S)-Nutlin carboxylic acid-NHC2-PEG1-N3 is an E3 ligase ligand-linker conjugate that features the (4R,5S)-Nutlin carboxylic acid component, which targets MDM2. This compound enables the design of PROTACs by linking to a target protein, facilitating targeted protein degradation. It is particularly useful in research applications focused on modulating EZH2 levels and investigating E3 ligase functionalities in cellular systems.
Product Information
Catalog NumA80317
FormulaC36H40Cl2N8O6
Molecular Weight751.66
CAS Number2977227-58-8
SMILESO=C(N1CC(N(CC1)CC(NCCOCCN=[N+]=[N-])=O)=O)N2[C@@H](C3=CC=C(C=C3)Cl)[C@@H](C4=CC=C(C=C4)Cl)N=C2C5=C(C=C(C=C5)OC)OC(C)C
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