5,6-Dihydro-5-Fluorouracil-13C,15N2 is a stable isotope-labeled derivative of 5,6-Dihydro-5-Fluorouracil, which acts as a thymidylate synthase inhibitor through its active metabolite formation from the prodrug 5-fluorouracil via dihydropyrimidine dehydrogenase. This compound demonstrates cytotoxic effects on HaCaT keratinocytes with an IC50 of 13.5 μM. Research applications include investigating tumor growth inhibition, particularly in combination with 5-fluorouracil and dihydropyrimidine dehydrogenase inhibitors, in oncological studies such as rat colon cancer models.
5,6-Dihydro-5-Fluorouracil-13C,15N2 is a stable isotope-labeled derivative of 5,6-Dihydro-5-Fluorouracil, which acts as a thymidylate synthase inhibitor through its active metabolite formation from the prodrug 5-fluorouracil via dihydropyrimidine dehydrogenase. This compound demonstrates cytotoxic effects on HaCaT keratinocytes with an IC50 of 13.5 μM. Research applications include investigating tumor growth inhibition, particularly in combination with 5-fluorouracil and dihydropyrimidine dehydrogenase inhibitors, in oncological studies such as rat colon cancer models.
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