5,7-Dichlorokynurenic acid sodium serves as a selective and competitive antagonist at the glycine site of the NMDA receptor, exhibiting a KB of 65 nM. This compound effectively reduces neuron injury induced by NMDA and demonstrates significant anxiolytic-like effects in rodent models, including increased social interaction and open arm exploration. Its application in research supports investigations into the role of glycine in NMDA receptor-mediated synaptic transmission and associated behavioral outcomes.
5,7-Dichlorokynurenic acid sodium serves as a selective and competitive antagonist at the glycine site of the NMDA receptor, exhibiting a KB of 65 nM. This compound effectively reduces neuron injury induced by NMDA and demonstrates significant anxiolytic-like effects in rodent models, including increased social interaction and open arm exploration. Its application in research supports investigations into the role of glycine in NMDA receptor-mediated synaptic transmission and associated behavioral outcomes.
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