Neuronal Signaling

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  1. RO4929097

    Catalog No. A10802
    Gamma-secretase inhibitor
    RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. Learn More
  2. BMS-708163 (Avagacestat)

    Catalog No. A10157
    Gamma-secretase inhibitor
    BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis. Learn More
  3. MK-0752

    Catalog No. A11194
    Gamma-secretase inhibitor
    MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. Learn More
  4. LY2811376

    Catalog No. A11776
    BACE1 inhibitor
    LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals. Learn More
  5. Dimebon 2HCl

    Catalog No. A10312
    Neuroprotectant
    Dimebon dihydrochloride is a non-selective antihistamine that displays cognitive enhancing abilities. Learn More
  6. Ro 90-7501

    Catalog No. A12647
    amyloid β42 inhibitor
    Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM). Learn More
  7. Amyloid b-Protein (1-15)

    Catalog No. A15424
    Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid. Learn More
  8. beta-Amyloid (1-11)

    Catalog No. A15423
    Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein. Learn More
  9. Amyloid b-Peptide (1-43) (human), amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42. Learn More
  10. Amyloid b-peptide (1-42) (rat) Learn More
  11. Amyloid b-peptide (1-40) (rat) Learn More
  12. Amyloid b-Peptide (1-40) (human) is a peptide processed from the amyloid precursor protein (APP). Learn More
  13. Amyloid b-peptide (25-35) (human), fragment of human amyloid beta-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease. Learn More
  14. Amyloid b-Peptide (12-28) (human), amyloid b-peptide fragment; minimum section required to bind to brain proteins. Learn More
  15. Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17. Learn More
  16. Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide. Learn More
  17. Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Learn More
  18. DAPT (GSI-IX)

    Catalog No. A10288
    Gamma secretase inhibitor
    DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. Learn More
  19. YO-01027

    Catalog No. A11174
    γ-secretase inhibitor
    YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent. Learn More
  20. LY-411575

    Catalog No. A11176
    Gamma secretase inhibitor

    LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

    Learn More
  21. Semagacestat (LY450139)

    Catalog No. A10836
    Gamma-secretase inhibitor
    Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM. Learn More
  22. BMS 433796

    Catalog No. A11337
    γ-Secretase Inhibitor
    BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease. Learn More
  23. E 2012

    Catalog No. A11393
    gamma-secretase modulator
    E 2012 is γ-secretase inhibitor. Learn More
  24. BMS 299897

    Catalog No. A12444
    γ-secretase inhibitor
    BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Learn More
  25. Flurizan

    Catalog No. A12433
    gamma-secretase modulator
    Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Learn More
  26. FLI-06

    Catalog No. A13815
    Gamma-secretase inhibitor
    FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. Learn More
  27. LY3039478

    Catalog No. A13544
    Notch inhibitor
    LY3039478 is a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested. Learn More
  28. gamma-secretase modulator
    gamma-secretase modulator 3 is a gamma-secretase modulator. Learn More
  29. Compound W

    Catalog No. A15296
    Gamma-secretase modulator
    Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25. Learn More
  30. JLK 6

    Catalog No. A15301
    γ-secretase inhibitor
    JLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways. Learn More
  31. MRK 560

    Catalog No. A15304
    γ-secretase inhibitor
    MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo. Learn More
  32. PF-03084014

    Catalog No. A11259
    γ-secretase inhibitor
    PF-03084014 is a reversible and selective inhibitor of γ-secretase with IC50 value of 6.2 nM . Learn More
  33. Flurbiprofen Axetil

    Catalog No. A13662
    gamma-secretase inhibitor
    Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID). Learn More
  34. L-685458

    Catalog No. A15899
    γ-secretase inhibitor
    L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. Learn More
  35. Begacestat (GSI-953)

    Catalog No. A11258
    γ-secretase inhibitor
    Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. Learn More
  36. Gamma-secretase modulator
    gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease. Learn More
  37. Gamma-secretase modulator
    gamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease. Learn More
  38. TC-E 5006

    Catalog No. A13217
    Gamma-secretase modulator
    TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Learn More
  39. IMR-1

    Catalog No. A16152
    Notch inhibitor
    IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L. Learn More
  40. CHF5074

    Catalog No. A16214
    γ-Secretase modulator
    CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively. Learn More
  41. Z-Ile-Leu-aldehyde

    Catalog No. A16215
    γ-Secretase inhibitor
    Z-Ile-Leu-aldehyde is a potent gamma-Secretase inhibitor; Notch signaling inhibitor. Learn More
  42. IMR-1A

    Catalog No. A16223
    Notch inhibitor
    IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L. Learn More
  43. LY-900009

    Catalog No. A14088
    Notch inhibitor
    LY-900009 is a potent inhibitor of Notch with IC50 value of 0.27 nM. Learn More
  44. LY2886721

    Catalog No. A10543
    BACE1 inhibitor
    LY2886721 is a novel potent agent that is used to treat Alzheimer's Disease in preclinical experiments. Learn More
  45. AZD3839

    Catalog No. A12825
    BACE1 inhibitor
    AZD3839 is a potent and selective inhibitor of human BACE1 with Ki of 26.1 nM. Learn More
  46. AZD5423

    Catalog No. A13249
    nonsteroidal glucocorticoid receptor agonist
    AZD5423 is a novel nonsteroidal glucocorticoid receptor agonist. Learn More
  47. AMG-8718

    Catalog No. A14407
    BACE1 inhibitor
    AMG-8718 is a potent and orally efficacious BACE1 inhibitor. Learn More
  48. Timosaponin b-II

    Catalog No. A14591
    BACE1 Inhibitor
    Timosaponin B-II is a major active component of Anemarrhena asphodeloides Bunge (Liliaceae, rhizome) that has protective effects against cerebral ischaemic damage. Learn More
  49. Verubecestat (MK-8931)

    Catalog No. A16113
    β-secretase/BACE1 inhibitor
    Verubecesta is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Learn More

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