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$0.00 Neuronal Signaling
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Aftin-4
Catalog No. A17139 Amyloid-β42 InducerAftin-4 is an amyloid-β42 inducer that electively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Learn More -
gamma-Secretase Modulators
Catalog No. A11426 Amyloid-β production inhibitorgamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. gamma-Secretase Modulators is useful for Alzheimer's disease. Learn More -
RO4929097
Catalog No. A10802 Gamma-secretase inhibitorRO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. Learn More -
ARN2966
Catalog No. A21016 APP expression modulatorARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. Learn More -
BMS-708163 (Avagacestat)
Catalog No. A10157 Gamma-secretase inhibitorBMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis. Learn More -
MK-0752
Catalog No. A11194 Gamma-secretase inhibitorMK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. Learn More -
LY2811376
Catalog No. A11776 BACE1 inhibitorLY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals. Learn More -
Dimebon 2HCl
Catalog No. A10312 NeuroprotectantDimebon dihydrochloride is a non-selective antihistamine that displays cognitive enhancing abilities. Learn More -
Ro 90-7501
Catalog No. A12647 amyloid β42 inhibitorRo 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM). Learn More -
Amyloid b-Protein (1-15)
Catalog No. A15424 Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid. Learn More -
beta-Amyloid (1-11)
Catalog No. A15423 Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein. Learn More -
Amyloid b-Peptide (1-43) (human)
Catalog No. A15421 Amyloid b-Peptide (1-43) (human), amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42. Learn More -
Amyloid b-Peptide (1-40) (human)
Catalog No. A15418 Amyloid b-Peptide (1-40) (human) is a peptide processed from the amyloid precursor protein (APP). Learn More -
Amyloid b-peptide (25-35) (human)
Catalog No. A15416 Amyloid b-peptide (25-35) (human), fragment of human amyloid beta-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease. Learn More -
Amyloid b-Peptide (12-28) (human)
Catalog No. A15417 Amyloid b-Peptide (12-28) (human), amyloid b-peptide fragment; minimum section required to bind to brain proteins. Learn More -
Amyloid b-Peptide (10-20) (human)
Catalog No. A15415 Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17. Learn More -
Amyloid b-peptide (42-1) (human)
Catalog No. A15414 Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide. Learn More -
Amyloid b-Peptide (1-42) (human)
Catalog No. A14075 Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Learn More -
alpha-Amyloid Precursor Protein Modulator
Catalog No. A13094 alpha-Amyloid Precursor Protein Modulator is a cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblas. Learn More -
DAPT (GSI-IX)
Catalog No. A10288 Gamma secretase inhibitorDAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. Learn More -
YO-01027
Catalog No. A11174 γ-secretase inhibitorYO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent. Learn More -
LY-411575
Catalog No. A11176 Gamma secretase inhibitorLY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.
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Semagacestat (LY450139)
Catalog No. A10836 Gamma-secretase inhibitorSemagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM. Learn More -
BMS 433796
Catalog No. A11337 γ-Secretase InhibitorBMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease. Learn More -
BMS 299897
Catalog No. A12444 γ-secretase inhibitorBMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo. Learn More -
Flurizan
Catalog No. A12433 gamma-secretase modulatorFlurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Learn More -
FLI-06
Catalog No. A13815 Gamma-secretase inhibitorFLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. Learn More -
LY3039478
Catalog No. A13544 Notch inhibitorLY3039478 is a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested. Learn More -
gamma-secretase modulator 3
Catalog No. A15090 gamma-secretase modulatorgamma-secretase modulator 3 is a gamma-secretase modulator. Learn More -
Compound W
Catalog No. A15296 Gamma-secretase modulatorCompound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25. Learn More -
JLK 6
Catalog No. A15301 γ-secretase inhibitorJLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways. Learn More -
MRK 560
Catalog No. A15304 γ-secretase inhibitorMRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo. Learn More -
PF-03084014
Catalog No. A11259 γ-secretase inhibitorPF-03084014 is a reversible and selective inhibitor of γ-secretase with IC50 value of 6.2 nM . Learn More -
Flurbiprofen Axetil
Catalog No. A13662 gamma-secretase inhibitorFlurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID). Learn More -
L-685458
Catalog No. A15899 γ-secretase inhibitorL-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. Learn More -
Begacestat (GSI-953)
Catalog No. A11258 γ-secretase inhibitorBegacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. Learn More -
gamma-secretase modulator 1
Catalog No. A11425 Gamma-secretase modulatorgamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease. Learn More -
gamma-secretase modulator 2
Catalog No. A11427 Gamma-secretase modulatorgamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease. Learn More -
TC-E 5006
Catalog No. A13217 Gamma-secretase modulatorTC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Learn More -
IMR-1
Catalog No. A16152 Notch inhibitorIMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L. Learn More -
CHF5074
Catalog No. A16214 γ-Secretase modulatorCHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively. Learn More -
Z-Ile-Leu-aldehyde
Catalog No. A16215 γ-Secretase inhibitorZ-Ile-Leu-aldehyde is a potent gamma-Secretase inhibitor; Notch signaling inhibitor. Learn More -
IMR-1A
Catalog No. A16223 Notch inhibitorIMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L. Learn More -
BMS-906024
Catalog No. A21172 gamma secretase inhibitorBMS-906024 is an oral and selective gamma secretase inhibitor (GSI) that is a small molecule Notch inhibitor. Learn More -
Compound E
Catalog No. A21292 -
LY-900009
Catalog No. A14088 Notch inhibitorLY-900009 is a potent inhibitor of Notch with IC50 value of 0.27 nM. Learn More -
NGP-555
Catalog No. A17051 γ-Secretase ModulatorNGP-555 is a gamma-secretase modulator with a selective mechanism to reduce Abeta 42 while raising shorter Abeta forms such as Abeta 37 and 38. Learn More
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