5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine binding site on the NMDA receptor, exhibiting a KB value of 65 nM. This compound effectively reduces NMDA-induced neuronal injury and enhances social interaction and exploration behaviors in rodent models. Additionally, 5,7-DCKA demonstrates anxiolytic-like effects, facilitating research into the role of glycine in NMDA receptor-mediated synaptic activity and associated psychiatric disorders.
5,7-Dichlorokynurenic acid (5,7-DCKA) is a selective and competitive antagonist of the glycine binding site on the NMDA receptor, exhibiting a KB value of 65 nM. This compound effectively reduces NMDA-induced neuronal injury and enhances social interaction and exploration behaviors in rodent models. Additionally, 5,7-DCKA demonstrates anxiolytic-like effects, facilitating research into the role of glycine in NMDA receptor-mediated synaptic activity and associated psychiatric disorders.
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