Fig. 1 · Structure
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5-Fluorouracil-d1
Stable Isotope
5-Fluorouracil-d1 is a deuterium-labeled analogue of the antitumor agent 5-Fluorouracil (5-FU). It primarily targets thymidylate synthetase, thereby inhibiting pyrimidine synthesis and depleting intracellular dTTP pools, which can lead to apoptosis in cancer cells. Additionally, 5-Fluorouracil is recognized for its potential as a chemical sensitizer and demonstrates inhibitory effects against HIV. This stable isotope variant is valuable for research applications involving metabolic studies and drug mechanism investigations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 90344-84-6 |
| Applications | Stable Isotope |
| Formula | C4H2DFN2O2 |
| Molecular Weight | 131.08 |
| Synonyms | 5-FU-d1 |
| SMILES | O=C1C(F)=C([2H])NC(N1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.