5-Fluorouracil-d1 is a deuterium-labeled analogue of the antitumor agent 5-Fluorouracil (5-FU). It primarily targets thymidylate synthetase, thereby inhibiting pyrimidine synthesis and depleting intracellular dTTP pools, which can lead to apoptosis in cancer cells. Additionally, 5-Fluorouracil is recognized for its potential as a chemical sensitizer and demonstrates inhibitory effects against HIV. This stable isotope variant is valuable for research applications involving metabolic studies and drug mechanism investigations.
5-Fluorouracil-d1 is a deuterium-labeled analogue of the antitumor agent 5-Fluorouracil (5-FU). It primarily targets thymidylate synthetase, thereby inhibiting pyrimidine synthesis and depleting intracellular dTTP pools, which can lead to apoptosis in cancer cells. Additionally, 5-Fluorouracil is recognized for its potential as a chemical sensitizer and demonstrates inhibitory effects against HIV. This stable isotope variant is valuable for research applications involving metabolic studies and drug mechanism investigations.
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