Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
3-O-Methyl Colterol-d9 is a deuterium-labeled analog of 3-O-Methyl Colterol. This stable isotope is utilized in analytical studies to track metabolic pathways and quantify interactions in biological systems. Its primary applications include pharmacokinetic studies and the investigation of drug metabolism, enhancing the understanding of biological processes involving beta-adrenergic receptors. -
Stable Isotope
Atenolol-d6 is a deuterium-labeled variant of the cardioselective β1-adrenergic receptor blocker, Atenolol. It exhibits a Ki of 697 nM at the β1-adrenoceptor in guinea pig left ventricle membranes. This stable isotope is instrumental in pharmacokinetic studies and research focused on hypertension and angina pectoris, allowing for improved metabolic tracing and analytical characterization in various biological assays. -
Derivative of Clonidine
Acetylclonidine is a derivative of Clonidine that targets imidazoline and adrenergic receptors. It exhibits biological activity in reducing intraocular pressure, making it a valuable reagent for research into ocular antihypertensive agents for the treatment of glaucoma. Its unique profile may provide insights into novel therapeutic approaches in ocular health. -
Desfluorinated Nebivolol Isomer
Desfluoro nebivolol is a desfluorinated isomer of the antihypertensive agent nebivolol, primarily acting as a beta-adrenergic receptor blocker. This compound exhibits pharmacological activity related to cardiovascular regulation, making it relevant for research in hypertension and heart failure therapies. Its unique chemical structure allows for exploration of β-blockade mechanisms and potential therapeutic benefits, providing valuable insights for the development of cardiovascular treatments. -
Drug Derivative
Cetamolol is a drug derivative that primarily targets beta-adrenergic receptors. It exhibits significant cardioprotective effects and is utilized in research focusing on cardiovascular pharmacology. Its ability to modulate heart rate and blood pressure makes it valuable for investigating hypertension and related cardiovascular disorders. -
α1 Adrenergic Receptor Agonist
Phenylephrine hydrochloride is an α1 adrenergic receptor agonist primarily used as a sympathomimetic agent. It induces vasoconstriction and increases perfusion pressure, making it valuable in clinical settings for managing hypotension and as a decongestant. Researchers utilize Phenylephrine hydrochloride to study cardiovascular responses and the pharmacological effects of adrenergic activation in various biological systems. -
Drug Impurity
Mirabegron impurity 10 is a known impurity associated with the pharmacological agent Mirabegron, a selective beta-3 adrenergic receptor agonist. It is crucial for studies focused on drug purity and stability, as well as for understanding the synthesis and degradation pathways of Mirabegron. This impurity serves as a reference standard for analytical methods and quality control processes in pharmaceutical development and research applications. -
Drug Impurity
Salbutamol impurity 7 is a known impurity of the bronchodilator Salbutamol, which primarily targets beta-2 adrenergic receptors. This compound is important for analytical research and quality control in pharmaceutical development to ensure the purity and safety of Salbutamol formulations. Its presence can influence pharmacokinetics and therapeutic efficacy, making it relevant for studies focused on drug metabolism and impurities. -
Stable Isotope
1-Oxo Colterol-d9 is a deuterium-labeled analog of 2-(Tert-butylamino)-1-(3,4-dihydroxyphenyl)ethan-1-one, serving as a stable isotope standard. This compound is valuable for quantitative mass spectrometry applications in biochemical research, particularly in studies involving adrenergic receptor signaling and pharmacokinetics. Its incorporation of deuterium enables precise tracking and analysis of metabolic pathways, enhancing the understanding of drug metabolism and activity. -
Stable Isotope
5'-Hydroxyphenyl carvedilol-d5 is a stable isotope-labeled analogue of carvedilol, targeting beta-adrenergic receptors. This deuterated compound is useful in pharmacokinetic studies, enabling the tracing of metabolic pathways and the assessment of drug disposition in various biological systems. Its structural modifications enhance the sensitivity and accuracy of analytical methods, making it an essential reagent for research applications in cardiovascular pharmacology and drug development. -
Adrenergic Receptor Antagonist
Yohimbine-d3 is a deuterated derivative of Yohimbine, functioning as an adrenergic receptor antagonist. This compound is utilized in research to study the modulation of adrenergic signaling pathways, specifically the alpha-2 adrenergic receptors. Its applications include investigations into the effects of adrenergic blockade on physiological processes and the potential therapeutic roles in conditions such as depression and sexual dysfunction. -
Stable Isotope
Dexmedetomidine-d4 L-tartrate (-d4-major) is a deuterium-labeled derivative of Dexmedetomidine L-tartrate, serving as a stable isotope for research applications. This compound is primarily utilized in pharmacokinetic studies and metabolic labeling, enabling accurate tracking of drug disposition and action mechanisms. It supports investigations into alpha-2 adrenergic receptor modulation and sedation research, providing insights into the pharmacological properties of its parent compound. -
Stable Isotope
(R)-(+)-Celiprolol-d9 hydrochloride is a deuterium-labeled analogue of the racemic beta-blocker Celiprolol, primarily targeting beta-adrenergic receptors. This stable isotope derivative facilitates precise pharmacokinetic studies and isotopic labeling experiments in chemical research. Its unique properties make it suitable for applications in metabolomics, drug metabolism, and tracer studies to elucidate the pharmacodynamics of beta-blockers. -
Stable Isotope
Labetalol hydrochloride-d5 is a deuterium-labeled form of Labetalol hydrochloride, specifically designed as a stable isotope for research applications. This compound functions as a selective α1-adrenergic and non-selective β-adrenergic receptor antagonist, primarily utilized for its antihypertensive properties. It is suitable for studying cardiovascular conditions, including hypertension, especially in contexts such as pregnancy where blood pressure regulation is critical. The stable isotope labeling facilitates advanced pharmacokinetic and metabolic studies. -
Biochemical Assay Reagent Control
Clenhexerol is a selective beta-adrenergic agonist that primarily targets beta-2 adrenergic receptors. This compound exhibits biological activity by stimulating smooth muscle relaxation and inducing bronchodilation. It is commonly used as a biochemical assay reagent control in research focused on respiratory diseases, pharmacological studies, and the exploration of adrenergic signaling pathways. -
Propranolol Analogue
KP-19 is a Propranolol analogue that targets β-adrenergic receptors, influencing cardiac function and stress response. This compound exhibits potential biological activity in modulating cardiovascular mechanisms and offers insights into the treatment of cardiovascular diseases. Its application in research may contribute to understanding therapeutic strategies for managing heart-related conditions. -
Intermediate
4-Propionamidophenol is an important intermediate in the synthesis of alkanolamine derivatives, primarily targeting β-adrenergic receptors. This compound exhibits significant β-adrenergic blocking activity, making it useful for research into cardiovascular conditions, including heart disease and hypertension. Its utility in synthesizing related compounds enhances its potential for various pharmacological studies. -
Drug Derivative
Indanazoline is a drug derivative that acts primarily as a selective vasoconstrictor. It exhibits significant vasoconstrictive activity through its interactions with adrenergic receptors, making it valuable in cardiovascular research. This compound can be utilized in studies focusing on blood pressure regulation and vascular dynamics, contributing to the understanding of hypertensive conditions and related pharmacological treatments. -
Drug Derivative
TA-993 is a drug derivative that enhances limb blood flow primarily through the modulation of the sympathetic nervous system, bypassing adrenergic receptors. This compound demonstrates a distinctive mechanism of action, potentially influencing heart rate through alternative pathways. TA-993 is valuable for research applications focused on understanding vascular dynamics and autonomic control in various physiological and pathological states. -
Vasoconstrictor Agent
Nordefrin, a derivative of norepinephrine, functions primarily as a vasoconstrictor agent. It exerts its biological activity by stimulating adrenergic receptors, leading to increased vascular resistance and elevated blood pressure. This compound is commonly utilized in research investigations focused on cardiovascular physiology and pharmacology, particularly those exploring blood pressure regulation and vascular function. -
Guanfacine Derivative
Etiguanfacine is a derivative of Guanfacine that primarily targets alpha-2 adrenergic receptors. It exhibits potential for reducing gastrointestinal side effects commonly associated with Guanfacine, making it a valuable tool for research into improved therapeutic profiles. This compound can be utilized in studies involving hypertension and attention-deficit hyperactivity disorder (ADHD), as well as in evaluating receptor-mediated mechanisms in neuropharmacology. -
Drug Derivative
Fepradinol is a drug derivative that primarily acts as a selective modulator of adrenergic receptors. This compound exhibits significant biological activity in influencing cardiovascular responses and can be utilized in research focused on cardiovascular pharmacology. Its modulatory effects make it valuable for investigating the therapeutic potential in treating various cardiovascular disorders. -
Drug Derivative
Methoserpidine is a drug derivative that primarily functions as an antagonist of the alpha-adrenergic receptor. This compound exhibits significant biological activity in modulating cardiovascular responses and neurotransmitter release, making it useful for research in hypertension and other cardiovascular disorders. Its properties enable exploration of adrenergic signaling pathways and may provide insights into potential therapeutic strategies. -
Dexoxadrol Enantiomer
Levoxadrol is the active enantiomer of dexoxadrol, primarily targeting adrenergic receptors. This compound exhibits potent agonistic activity, making it valuable for research applications in cardiovascular and neuropharmacology studies. Its distinct biological properties facilitate investigations into adrenergic signaling pathways and their role in various physiological and pathological conditions. -
Nasal Vasoconstrictor
Tymazoline hydrochloride is an imidazoline derivative known for its nasal vasoconstrictor properties. It acts primarily on alpha-adrenergic receptors, leading to the reduction of nasal mucosal edema. This compound is valuable in research applications related to rhinitis and other conditions involving nasal congestion. -
Pressor/Sympathomimetic Agent
Gepefrine is an orally active sympathomimetic agent with pressor properties. It primarily targets adrenergic receptors, enhancing vascular response and improving arterial pressure regulation. Gepefrine is utilized in research to study its effects on orthostatic dysregulation and cardiovascular dynamics. -
Endogenous Metabolite
AZD-3199 is an ultra-long-acting beta2 adrenergic agonist primarily targeting the beta2 adrenergic receptor. It exhibits significant bronchodilator activity, making it a candidate for therapeutic use in asthma and chronic obstructive pulmonary disease (COPD) research. Its prolonged action facilitates investigations into novel treatment strategies for managing these respiratory conditions. -
NR4A1 Inhibitor
Glycerol kinase, microorganism functions as an NR4A1 inhibitor by directly binding to and inhibiting the transcription factor NR4A1, which plays a critical role in hepatic gluconeogenesis. This inhibition leads to reduced blood glucose levels and positively influences UCP1 expression through the β-adrenergic receptor-cAMP-CREB signaling pathway, promoting the browning of white adipose tissue and enhancing thermogenesis. Additionally, it modulates intracellular fatty acid composition and energy metabolism. Research using glycerol kinase in diabetic mouse models has demonstrated its ability to counteract NR4A1-induced hyperglycemia, indicating its potential applications in diabetes and obesity studies. -
NR2B Antagonist
NMDA-IN-1 dihydrochloride is a selective antagonist of the NMDA NR2B receptor, exhibiting a Ki of 0.85 nM and an IC50 of 9.7 nM for NR2B-mediated Ca2+ influx. This compound effectively inhibits Glu/Gly-stimulated Ca2+ flux in Ltk- cells expressing hNR1a/NR2B, demonstrating specificity as it does not interact with NR2A, NR2C, NR2D, hERG channels, or α1-adrenergic receptors. NMDA-IN-1 dihydrochloride displays significant efficacy in mechanical hyperalgesia models in rats and is relevant for investigations into stroke, Parkinson's disease, and neuropathic pain. -
Stable Isotope
O-Desmethyl carvedilol-d5 is a deuterium-labeled derivative of O-Desmethylcarvedilol, a potent active metabolite of the non-selective β-adrenergic receptor antagonist Carvedilol. This compound exhibits inhibitory effects on store-overload-induced calcium release in HEK293 cells expressing the RyR2 R4496C mutation, with an IC50 of 7.62 μM. Additionally, O-Desmethyl carvedilol-d5 contributes to cardiovascular research by attenuating heart rate increases and stabilizing diastolic blood pressure in response to Isoproterenol in conscious rabbit models, demonstrating ED50 values of 32 and 5 μg/kg, respectively. -
Neuropeptide
BNP(1-32), porcine is an atrial natriuretic peptide that primarily targets neuropeptide pathways. This cardiac hormone exhibits significant natriuretic, diuretic, and vasorelaxant effects, making it valuable for cardiovascular research. Furthermore, BNP(1-32) has been shown to influence passive avoidance learning in rodent models, highlighting its potential role in neurobiology studies involving dopaminergic and cholinergic systems, as well as adrenergic receptor interactions. -
mAChR Antagonist
4-Piperidyl N-(2-biphenyl)carbamate is a competitive antagonist of muscarinic acetylcholine receptors (mAChR), exhibiting notable selectivity for the M2 and M3 subtypes. With pKi values of 7.33 for M2 and 7.51 for M3, this compound demonstrates a markedly higher affinity compared to β2 adrenergic receptors, which has a pKi of 4.94. This specificity makes it a valuable tool for research into mAChR-related signaling pathways and potential therapeutic applications in various neurological disorders. -
Drug Impurity
Tamsulosin impurity 14 is a known impurity associated with the pharmaceutical compound Tamsulosin, primarily targeting alpha-1 adrenergic receptors. This impurity is significant for quality control and analytical studies in drug development, particularly in determining the purity and stability of Tamsulosin formulations. Its characterization is essential for compliance with pharmaceutical regulations and ensuring therapeutic efficacy. -
Drug Impurity
Mirabegron impurity 4 is a chemical impurity associated with the drug Mirabegron, a beta-3 adrenergic receptor agonist. This impurity is important for assessing the purity and quality of Mirabegron formulations in pharmaceutical research. Its characterization is crucial for ensuring compliance with regulatory standards and for conducting stability studies in drug development. -
Nantenine Isomer
(R)-Nantenine is the levorotatory isomer of Nantenine, with a high affinity and selectivity for the α1A adrenergic receptor. This compound effectively blocks the behavioral suppression associated with 3,4-methylenedioxymethamphetamine (MDMA). Research applications for (R)-Nantenine primarily involve the study of disorders linked to MDMA abuse, providing valuable insights into its neuropharmacological effects. -
α2-Adrenergic Receptors Agonist
Methyldopa, an α2-adrenergic receptor agonist, is a potent antihypertensive compound. Acting as a proagent, it is metabolized to α-Methylepinephrine within the central nervous system, contributing to its effects on blood pressure regulation. This compound is primarily utilized in research applications focused on cardiovascular physiology and the modulation of neurogenic control of vascular tone. -
β-Adrenergic Agonist
Ritodrine hydrochloride is a potent β-adrenergic agonist that primarily targets β-adrenergic receptors. It is recognized for its ability to relax uterine smooth muscle and is utilized in the research of preterm labor management. Ritodrine hydrochloride is valuable for studying the mechanisms of uterine contractions and the pharmacological intervention of premature delivery. -
β-Adrenergic Receptor Blocker
Sotalol hydrochloride is a non-selective β-adrenergic receptor blocker that exhibits potent antiarrhythmic activity. It is utilized in research focused on pediatric arrhythmias and demonstrates efficacy by blocking β-receptors and the potassium channel KCNH2. Additionally, Sotalol hydrochloride holds potential applications as an antiepileptic agent, facilitating further studies into its diverse pharmacological effects. -
β-Adrenergic Antagonist
Levobetaxolol hydrochloride is a selective β-adrenergic antagonist primarily used in the treatment of ocular hypertension. This compound effectively reduces intraocular pressure, making it valuable for research related to glaucoma and other eye disorders. Investigations into its pharmacological profile can advance understanding of adrenergic receptor modulation in ocular applications. -
Adrenergic Receptor Antagonist
Tolazoline hydrochloride is an α-adrenergic receptor antagonist that effectively inhibits noradrenaline-induced smooth muscle contraction. This compound modulates vascular resistance, increases arterial pressure, and serves as an intervention for bradycardia and tachypnea. Tolazoline hydrochloride is utilized in research focused on erectile dysfunction, α2-adrenergic receptor agonist-related poisoning, and skin vascular diseases, making it a valuable tool for studying vascular responses and related pathologies. -
Endogenous Metabolite
Tyramine is an endogenous metabolite primarily involved in the regulation of blood pressure through its interaction with adrenergic receptors. It plays a significant role in neurotransmission and the modulation of vascular tone. Research applications of tyramine include studies focused on cardiovascular physiology, neurochemistry, and the exploration of dietary impacts on health. -
Drug Impurity
Atenolol impurity 8 is a structural impurity associated with Atenolol, a selective beta-1 adrenergic receptor blocker. This compound is crucial for analyzing the purity of Atenolol formulations and evaluating potential impacts on drug efficacy and safety. It serves as an important reference standard in the pharmaceutical industry for quality control and compliance in drug development and analysis. -
Drug Impurity
Tamsulosin impurity 21 is a chemical impurity associated with the drug Tamsulosin, which primarily targets the α1-adrenergic receptors. This impurity may serve as a valuable reference standard in the analysis of Tamsulosin formulations. Its identification is crucial for assessing the purity and quality of pharmaceutical products in drug development and quality control. -
Adrenergic Prodrug
Dibutepinephrine is an orally active adrenergic prodrug that targets adrenergic receptors. It demonstrates significant efficacy in rapidly alleviating allergic symptoms, making it a valuable tool for studying severe allergic reactions. This compound is useful in research focused on the mechanisms of allergic responses and the development of therapeutic interventions. -
Adrenergic Receptor Antagonist
Tolazoline is an α-adrenergic receptor antagonist that plays a critical role in modulating vascular responses. It inhibits noradrenaline-induced cell contraction, affects vascular resistance, increases arterial pressure, and can reverse both bradycardia and tachypnea. This compound is valuable for studying erectile dysfunction, assessing α2-adrenergic receptor agonist-related poisoning, and investigating skin vascular diseases. -
alpha-adrenoceptor Antagonist
Acepromazine is a phenothiazine tranquilizer primarily acting as an alpha-adrenoceptor antagonist. It exhibits sedative and tranquilizing effects by blocking the adrenergic receptors, which can be valuable in veterinary medicine. Acepromazine is commonly utilized in studies involving sedation, anesthesia, and behavioral research, making it an important reagent for exploring neuropharmacological pathways. -
Anti-adrenergic Agent, Anti-anginal Agent
L 8412 is a potent anti-adrenergic agent that primarily targets adrenergic receptors, leading to decreased heart rate and myocardial oxygen demand. It exhibits significant anti-anginal activity, making it valuable in cardiovascular research. This compound is utilized for studying the effects of adrenergic modulation on heart function and in the development of therapies for angina pectoris. -
Antihypertensive Agent
Alkaloids, Rauwolfia are derived from the root of Rauwolfia serpentina and act primarily as antihypertensive agents. These bioactive compounds have been shown to effectively lower blood pressure by targeting adrenergic receptors and modulating central nervous system activity. They are widely utilized in research to investigate hypertension and related cardiovascular conditions. -
Natural Extract
Yohimbe extract primarily targets adrenergic receptors due to its active component, yohimbine, an alkaloid. It is recognized for its biological activities, including the enhancement of sexual function, potential weight loss benefits, and promotion of blood circulation. This natural extract is widely utilized in pharmacological research and studies focused on cardiovascular health and metabolic regulation. -
Adrenergic Receptor Agonist
Norepinephrine tartrate is a potent adrenergic receptor agonist, primarily targeting α1, α2, and β1 receptors. Its key biological activity involves regulating vascular tone, heart rate, and metabolic processes. This compound is widely utilized in cardiovascular research, particularly in studies related to blood pressure modulation and the sympathetic nervous system's roles in various physiological conditions.
