7α,25-Dihydroxycholesterol is a potent agonist of the orphan G protein-coupled receptor GPR183 (EBI2). This compound exhibits high efficacy in activating EBI2, with an EC50 of 140 pM and a Kd of 450 pM. It plays a critical role in chemokine signaling, directing the migration of immune cells such as B cells, T cells, and dendritic cells, making it valuable for research in immunology and cell signaling pathways.
7α,25-Dihydroxycholesterol is a potent agonist of the orphan G protein-coupled receptor GPR183 (EBI2). This compound exhibits high efficacy in activating EBI2, with an EC50 of 140 pM and a Kd of 450 pM. It plays a critical role in chemokine signaling, directing the migration of immune cells such as B cells, T cells, and dendritic cells, making it valuable for research in immunology and cell signaling pathways.
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