8-Chloro-ATP is an analog of ATP that serves as a potent inhibitor of topoisomerase II (Topo II). This compound effectively inhibits DNA synthesis and induces the formation of DNA double-stranded breaks (DSBs) through its action on Topo II-catalyzed ATP hydrolysis. It is a valuable tool for research applications focused on understanding the mechanisms of DNA replication and the role of topoisomerases in cellular processes.
8-Chloro-ATP is an analog of ATP that serves as a potent inhibitor of topoisomerase II (Topo II). This compound effectively inhibits DNA synthesis and induces the formation of DNA double-stranded breaks (DSBs) through its action on Topo II-catalyzed ATP hydrolysis. It is a valuable tool for research applications focused on understanding the mechanisms of DNA replication and the role of topoisomerases in cellular processes.
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