8-Hydroxyoctanoic acid-thalidomide

Catalog No.: A80097
E3 Ligase Ligand-Linker Conjugate
8-Hydroxyoctanoic acid-thalidomide is an E3 ligase ligand-linker conjugate that facilitates the targeted degradation of proteins via the ubiquitin-proteasome pathway. This compound exhibits potent activities that support the development of targeted protein degradation strategies in chemical biology research. Additionally, it can be employed in the synthesis of Lw13 for further investigative studies into protein modulation and therapeutic applications.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description8-Hydroxyoctanoic acid-thalidomide is an E3 ligase ligand-linker conjugate that facilitates the targeted degradation of proteins via the ubiquitin-proteasome pathway. This compound exhibits potent activities that support the development of targeted protein degradation strategies in chemical biology research. Additionally, it can be employed in the synthesis of Lw13 for further investigative studies into protein modulation and therapeutic applications.
Product Information
Catalog NumA80097
FormulaC21H27N3O5
Molecular Weight401.46
CAS Number2399454-65-8
SMILESO=C(O)CCCCCCCNC1=C2C(C(N(C3CCC(NC3=O)=O)C2)=O)=CC=C1
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