9-Hydroxyellipticin is a potent inhibitor of topoisomerase II (Topo II) and ryanodine receptors (RyR), demonstrating high affinity for DNA with a pKa value of 9.8 at pH 7.4. This compound exhibits significant antitumor and antioxidant activities, with IC50 values of 1.6 μM in HeLa S-3 cells and 1.2 μM in 293T cells. Additionally, 9-hydroxyellipticin has shown promising anticancer effects in murine models of L1210 leukemia, making it a valuable reagent for cancer research and therapeutic studies.
9-Hydroxyellipticin is a potent inhibitor of topoisomerase II (Topo II) and ryanodine receptors (RyR), demonstrating high affinity for DNA with a pKa value of 9.8 at pH 7.4. This compound exhibits significant antitumor and antioxidant activities, with IC50 values of 1.6 μM in HeLa S-3 cells and 1.2 μM in 293T cells. Additionally, 9-hydroxyellipticin has shown promising anticancer effects in murine models of L1210 leukemia, making it a valuable reagent for cancer research and therapeutic studies.
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