9-Hydroxyellipticine hydrochloride is a potent inhibitor of topoisomerase II, targeting this essential enzyme involved in DNA replication and repair. This compound demonstrates significant antitumor activity, alongside antioxidant properties and catecholamine-releasing effects. In vitro studies reveal IC50 values of 1.6 μM and 1.2 μM in HeLa S-3 and 293T cell lines, respectively, highlighting its potential for cancer research applications.
9-Hydroxyellipticine hydrochloride is a potent inhibitor of topoisomerase II, targeting this essential enzyme involved in DNA replication and repair. This compound demonstrates significant antitumor activity, alongside antioxidant properties and catecholamine-releasing effects. In vitro studies reveal IC50 values of 1.6 μM and 1.2 μM in HeLa S-3 and 293T cell lines, respectively, highlighting its potential for cancer research applications.
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