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A-395

Catalog No.: A12999

PRC2 protein-protein interactions antagonist

A-395

A-395 Chemical Structure

CAS NO. 2089148-72-9

A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 of 18 nM.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$155.00
50 mg
$460.00
100 mg
$920.00
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Biological Activity

A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 of 18 nM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.55 mL 102.74 mL 205.49 mL
0.5 mM 4.11 mL 20.55 mL 41.1 mL
1 mM 2.05 mL 10.27 mL 20.55 mL
5 mM 0.41 mL 2.05 mL 4.11 mL

*The above data is based on the productmolecular weight 486.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12999
Actions Antagonist
CAS No. 2089148-72-9
Formula C26H35FN4O2S
M. Wt 486.65
Purity >98%
Synonyms A395, A 395
SMILES O=S(N1CCN(C2=CC=C([[email protected]]3CN(C4C(C(F)=CC=C5)=C5CC4)C[[email protected]@H]3N(C)C)C=C2)CC1)(C)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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