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Biological Activity
A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12) with an IC50 of 18 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.55 mL | 102.74 mL | 205.49 mL |
| 0.5 mM | 4.11 mL | 20.55 mL | 41.1 mL |
| 1 mM | 2.05 mL | 10.27 mL | 20.55 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.11 mL |
*The above data is based on the productmolecular weight 486.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12999 |
|---|---|
| Actions | Antagonist |
| CAS No. | 2089148-72-9 |
| Formula | C26H35FN4O2S |
| M. Wt | 486.65 |
| Purity | >98% |
| Synonyms | A395, A 395 |
| SMILES | O=S(N1CCN(C2=CC=C([[email protected]]3CN(C4C(C(F)=CC=C5)=C5CC4)C[[email protected]@H]3N(C)C)C=C2)CC1)(C)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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