A 803467

Name: A 803467
SKU: A11234

Catalog No.: A11234

Sodium channel Blocker

A 803467

A 803467 Chemical Structure

CAS NO. 944261-79-4

A 803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively).

Availability: In stock

Package	Price	Qty
10 mg	Regular Price: $50.00 Special Price $40.00
25 mg	Regular Price: $98.00 Special Price $78.40
50 mg	Regular Price: $150.00 Special Price $120.00
100 mg	Regular Price: $250.00 Special Price $200.00
10mM * 1mL in DMSO	$77.00

Price Match Request

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Nature 2017
551, 247-250

Science
2017; 356(6336)

Nat Chem Biol.
1, 713–720 (2015)

Nat Commun
2016; 7: 11051.

Nat Cell Biol. 2013
15(12):1473-85.

Cell 2014 Feb 27
156(5):986-1001.

Nat Commun
2015; 6: 7139.

PNAS 2014
111(43) 15514-15519

PNAS 2014
111(23) E2404-E2413

J Neurosci. 2015
35(5): 2101–2111

Scientific Reports
5, 12298.

Cell Research
225, 707–725.

Oncogene
2014, 1–14 .

Details

Biological Activity

A 803467 is a selective blocker of NaV1.8 channels (IC50 values are 8, 2450, 6740, 7340 and 7380 nM for hNaV1.8, hNaV1.3, hNaV1.7, hNaV1.5 and hNaV1.2 channels respectively).

Targets

Na(V1.8) channel
8 nM

Solubility *

In vitro (25°C)	DMSO	72 mg/mL (201.23 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	11 mg/mL (30.74 mM)
In vivo	30% PEG400/0.5% Tween80/5% propylene glycol	30 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.95 mL	139.74 mL	279.49 mL
0.5 mM	5.59 mL	27.95 mL	55.9 mL
1 mM	2.79 mL	13.97 mL	27.95 mL
5 mM	0.56 mL	2.79 mL	5.59 mL

*The above data is based on the productmolecular weight 357.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

View Related Products By Research Topics

Na(V1.8) channel

Technical Details

Catalog Num	A11234
Actions	Blocker
M. Wt	357.8
Formula	C19H16ClNO4
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	944261-79-4
Synonyms	A-803467, A803467
SMILES	COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl)OC