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A-86929

Dopamine D1 Receptor Agonist

A-86929 functions as a potent and selective agonist for the dopamine D1 receptor, exhibiting a pKi value of 7.3. It has been shown to significantly induce rotational behavior in the 6-OHDA-induced unilateral nigrostriatal lesion rat model and improve motor function in the MPTP-induced Parkinson's disease marmoset model. Additionally, A-86929 may provide therapeutic insights for reducing cocaine-seeking behavior in rat studies and reversing Haloperidol-induced cognitive deficits in rhesus monkeys. This compound is valuable for research focused on neurological disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	171961-95-8
Applications	Dopamine D1 Receptor Agonist
Formula	C₁₈H₂₁NO₂S
Molecular Weight	315.43
SMILES	CCCC1=CC([C@]2([H])C3=C4)=C(S1)CN[C@]2([H])CCC3=CC(O)=C4O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.