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A4333

Catalog No.: A77197
Phospholipase Inhibitor
A4333 is a biotinylated inhibitor of Phospholipase D1 (PLD1), selectively targeting this enzyme while sparing PLD2. This compound is significant in cancer research, demonstrating potent antitumor activity. Its specificity for PLD1 makes A4333 a valuable tool for elucidating the role of phospholipase signaling in tumor biology and potential therapeutic applications.
A4333 3025827-56-6 Phospholipase Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionA4333 is a biotinylated inhibitor of Phospholipase D1 (PLD1), selectively targeting this enzyme while sparing PLD2. This compound is significant in cancer research, demonstrating potent antitumor activity. Its specificity for PLD1 makes A4333 a valuable tool for elucidating the role of phospholipase signaling in tumor biology and potential therapeutic applications.
Product Information
Catalog NumA77197
FormulaC28H26F6N6O4S
Molecular Weight656.60
CAS Number3025827-56-6
SMILESO=C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C2=CC3=C(N2)C=CC(C(NNC(CCCC[C@H]4[C@](NC(N5)=O)([H])[C@]5([H])CS4)=O)=O)=C3
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Metabolism > Phospholipases