AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist, exhibiting an EC50 of 6 nM for ERβ and 5000 nM for ERα. This compound demonstrates pronounced neuroprotective effects in male rat models of Parkinson's disease, highlighting its potential application in studying gender-specific neuroprotection and ERβ-related biological pathways. Researchers may utilize AC-186 to explore the therapeutic implications of estrogenic signaling in neurodegenerative conditions.
AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist, exhibiting an EC50 of 6 nM for ERβ and 5000 nM for ERα. This compound demonstrates pronounced neuroprotective effects in male rat models of Parkinson's disease, highlighting its potential application in studying gender-specific neuroprotection and ERβ-related biological pathways. Researchers may utilize AC-186 to explore the therapeutic implications of estrogenic signaling in neurodegenerative conditions.
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