Acetalin-3

Catalog No.: A62453
μ Opioid Receptor Antagonist
Acetalin-3 (Ac-RFMWMT-NH2) is a hexapeptide that functions as a potent antagonist of the μ opioid receptor. It exhibits high affinity for both the μ and κ3 opioid receptors, while demonstrating weak affinity for the κ1 receptor and lack of affinity for the κ2 receptor. This compound is valuable in research applications focused on opioid signaling pathways and the development of analgesics while providing insights into opioid receptor interactions.
Grouped product items
Size Price Stock Qty
5mg
$350.00
In stock
10mg
$650.00
In stock
50mg
$2,000.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAcetalin-3 (Ac-RFMWMT-NH2) is a hexapeptide that functions as a potent antagonist of the μ opioid receptor. It exhibits high affinity for both the μ and κ3 opioid receptors, while demonstrating weak affinity for the κ1 receptor and lack of affinity for the κ2 receptor. This compound is valuable in research applications focused on opioid signaling pathways and the development of analgesics while providing insights into opioid receptor interactions.
Product Information
Catalog NumA62453
FormulaC42H61N11O8S2
Molecular Weight912.13
CAS Number152274-65-2
SequenceAc-Arg-Phe-Met-Trp-Met-Thr-NH2
Sequence shorteningAc-RFMWMT-NH2
SMILESC([C@@H](C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N)=O)=O)CCSC)=O)NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(=N)N)NC(C)=O)=O)=O)CCSC)=O)C=2C=3C(NC2)=CC=CC3
Useful Calculator

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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