Acetyl-Amyloid β-Protein (1-6) amide

Catalog No.: A78435
Amyloid-β
Acetyl-Amyloid β-Protein (1-6) amide is a hexapeptide targeting amyloid-β, which is implicated in the pathogenesis of Alzheimer’s disease. This compound features a potential copper(II) binding site, making it valuable for studies investigating metal ion interactions in neurodegenerative disorders. It is suitable for research aimed at understanding the molecular mechanisms of Alzheimer's disease and developing therapeutic strategies.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAcetyl-Amyloid β-Protein (1-6) amide is a hexapeptide targeting amyloid-β, which is implicated in the pathogenesis of Alzheimer’s disease. This compound features a potential copper(II) binding site, making it valuable for studies investigating metal ion interactions in neurodegenerative disorders. It is suitable for research aimed at understanding the molecular mechanisms of Alzheimer's disease and developing therapeutic strategies.
Product Information
Catalog NumA78435
FormulaC35H50N12O11
Molecular Weight814.85
CAS Number903883-22-7
SequenceAc-Asp-Ala-Glu-Phe-Arg-His-NH2
Sequence shorteningAc-DAEFRH-NH2
SMILESC[C@H](NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O
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