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AcLysValCit-PABC-DMAE-SW-163D

Catalog No.: A41490
Drug-Linker Conjugates for ADC
AcLysValCit-PABC-DMAE-SW-163D is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). This compound features the natural bis-intercalator SW-163D linked through the AcLysValCitPABC-DMAE moiety, facilitating targeted delivery of cytotoxic agents. It is instrumental in enhancing the efficacy of ADCs by improving specificity and reducing off-target effects in cancer research applications.
AcLysValCit-PABC-DMAE-SW-163D 2411007-69-5 Drug-Linker Conjugates for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAcLysValCit-PABC-DMAE-SW-163D is a drug-linker conjugate designed for antibody-drug conjugates (ADCs). This compound features the natural bis-intercalator SW-163D linked through the AcLysValCitPABC-DMAE moiety, facilitating targeted delivery of cytotoxic agents. It is instrumental in enhancing the efficacy of ADCs by improving specificity and reducing off-target effects in cancer research applications.
Product Information
Catalog NumA41490
FormulaC85H113N19O22S2
Molecular Weight1817.05
CAS Number2411007-69-5
SMILESC[C@H](NC1=O)C(N([C@H](C(N([C@]2(C(OC[C@@H](NC(C3=C(C=C4C(C=CC=C4)=N3)O)=O)C(N[C@H](C(N(C)[C@@H](CS5)C(N(C)[C@]6(C(OC[C@H]1NC(C7=C(C=C8C(C=CC=C8)=N7)OC(N(CCN(C(OCC9=CC=C(C=C9)NC([C@@H](NC([C@@H](NC([C@@H](CCCCN)NC(C)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=O)C)C)=O)=O)=O)[C@H](C6)C)=O)=O)C)=O)=O)[C@H](C2)C)C)=O)[C@H]5SC)C)=O
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC