Adenosine 3'-phosphate 5'-phosphosulfate is a selective antagonist of the P2Y1 receptor, effectively inhibiting ADP-induced platelet aggregation without affecting P2Y2, P2Y4, or P2Y6 receptors. This compound disrupts the ability of ADP to induce shape change and elevate intracellular Ca2+ levels in platelets while not influencing ADP's inhibition of adenylate cyclase. In addition to its antagonistic properties, Adenosine 3'-phosphate 5'-phosphosulfate serves as a co-substrate for glycan sulfonation, and can be utilized in Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays for sulfonate group transfer.
Adenosine 3'-phosphate 5'-phosphosulfate is a selective antagonist of the P2Y1 receptor, effectively inhibiting ADP-induced platelet aggregation without affecting P2Y2, P2Y4, or P2Y6 receptors. This compound disrupts the ability of ADP to induce shape change and elevate intracellular Ca2+ levels in platelets while not influencing ADP's inhibition of adenylate cyclase. In addition to its antagonistic properties, Adenosine 3'-phosphate 5'-phosphosulfate serves as a co-substrate for glycan sulfonation, and can be utilized in Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays for sulfonate group transfer.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
