ADX71441 is an orally active positive allosteric modulator of the GABAB receptor, capable of crossing the blood-brain barrier. With an EC50 of 96 nM, it enhances the effect of endogenous GABA, while also functionally inhibiting adenosine transporters and the 5-HT2B receptor. ADX71441 demonstrates a range of biological activities, including anxiolytic, analgesic, muscle relaxant, and hypothermic effects. Additionally, it reduces acute locomotor activity, decreases the voluntary intake of alcohol and saccharin, mitigates stress-induced neuronal activation, and exhibits anti-hyperalgesic properties, making it a valuable tool for research in neuropharmacology and related fields.
ADX71441 is an orally active positive allosteric modulator of the GABAB receptor, capable of crossing the blood-brain barrier. With an EC50 of 96 nM, it enhances the effect of endogenous GABA, while also functionally inhibiting adenosine transporters and the 5-HT2B receptor. ADX71441 demonstrates a range of biological activities, including anxiolytic, analgesic, muscle relaxant, and hypothermic effects. Additionally, it reduces acute locomotor activity, decreases the voluntary intake of alcohol and saccharin, mitigates stress-induced neuronal activation, and exhibits anti-hyperalgesic properties, making it a valuable tool for research in neuropharmacology and related fields.
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