Afizagabar (S44819) is a selective antagonist of the GABA-binding site at the α5-GABA receptor subtype, displaying an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. This compound has been shown to enhance synaptic plasticity within the hippocampus, thus demonstrating potential pro-cognitive effects. Afizagabar serves as a valuable tool for research focused on cognitive enhancement and the modulation of GABAergic signaling pathways.
Afizagabar (S44819) is a selective antagonist of the GABA-binding site at the α5-GABA receptor subtype, displaying an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. This compound has been shown to enhance synaptic plasticity within the hippocampus, thus demonstrating potential pro-cognitive effects. Afizagabar serves as a valuable tool for research focused on cognitive enhancement and the modulation of GABAergic signaling pathways.
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