AG-1024 (Tyrphostin)

Name: AG-1024 (Tyrphostin)
Brand: Adooq Bioscience
SKU: A11400
Rating: 100 (1 reviews)

Catalog No.: A11400

IGF-1R Inhibitor

Product Citations (1)

AG-1024 (Tyrphostin) Chemical Structure

CAS NO. 65678-07-1

AG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.

Availability: In stock

Package	Price	Qty
5 mg	$60.00
10 mg	$110.00
25 mg	$220.00
50 mg	$350.00
10mM * 1mL in DMSO	$70.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq AG-1024 (Tyrphostin)

Maeda A, .et al. Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-Ay mice., Mol Nutr Food Res. , 2014, 58(6):1177-89 PMID: 24668740

Biological Activity

Targets

IGF-1R	Insulin Receptor
7 μM	57 μM

Solubility *

In vitro (25°C)	DMSO	59 mg/mL (193.33 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.77 mL	163.83 mL	327.65 mL
0.5 mM	6.55 mL	32.77 mL	65.53 mL
1 mM	3.28 mL	16.38 mL	32.77 mL
5 mM	0.66 mL	3.28 mL	6.55 mL

*The above data is based on the productmolecular weight 305.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11400
Actions	Inhibitor
CAS No.	65678-07-1
Formula	C14H13BrN2O
M. Wt	305.2
Purity	>98%
Synonyms	AG1024
SMILES	CC(C)(C)C1=C(C(=CC(=C1)C=C(C#N)C#N)Br)O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.