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Biological Activity
AG-18 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 35 ,M in the human epidermoid carcinoma cell line A431.
Targets
| EGFR | ||||
| 35 μM |
| In vitro | DMSO | 34 mg/mL (182.63 mM) | |
| Water | Insoluble | ||
| Ethanol | 34 mg/mL (182.63 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 53.71 mL | 268.57 mL | 537.14 mL |
| 0.5 mM | 10.74 mL | 53.71 mL | 107.43 mL |
| 1 mM | 5.37 mL | 26.86 mL | 53.71 mL |
| 5 mM | 1.07 mL | 5.37 mL | 10.74 mL |
*The above data is based on the productmolecular weight 186.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15940 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 118409-57-7 |
| Formula | C10H6N2O2 |
| M. Wt | 186.17 |
| Purity | >98% |
| Synonyms | RG-50810, RG-50858, TX 825, Tyrphostin 23, Tyrphostin A23, Tyrphostin AG-18 |
| SMILES | N#C/C(C#N)=C/C1=CC=C(O)C(O)=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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