AG-205 is a selective antagonist of progesterone receptor membrane component 1 (PGRMC1), exhibiting a potent inhibitory effect on ceramide glucosyltransferase (CGT) with an IC50 of 50 μM in rat models. This compound demonstrates significant antimitotic, antimigratory, and anti-invasive properties, particularly in ovarian and breast cancer cells. AG-205 enhances the expression of genes involved in cholesterol biosynthesis and steroidogenesis while promoting apoptotic regulation of the cell cycle. Its diverse biological activity positions AG-205 as a valuable tool for investigating mechanisms underlying renal and breast cancer progression.
AG-205 is a selective antagonist of progesterone receptor membrane component 1 (PGRMC1), exhibiting a potent inhibitory effect on ceramide glucosyltransferase (CGT) with an IC50 of 50 μM in rat models. This compound demonstrates significant antimitotic, antimigratory, and anti-invasive properties, particularly in ovarian and breast cancer cells. AG-205 enhances the expression of genes involved in cholesterol biosynthesis and steroidogenesis while promoting apoptotic regulation of the cell cycle. Its diverse biological activity positions AG-205 as a valuable tool for investigating mechanisms underlying renal and breast cancer progression.
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