AGN-191659 is a potent agonist of retinoid X receptors (RXR) and retinoic acid receptors (RAR), exhibiting EC50 values of 11 nM, 23 nM, and 37 nM for RXRα, RARβ, and RARγ, respectively. It enhances gene transcription through activation of these receptors and has demonstrated significant biological activities, including the induction of tissue transglutaminase and suppression of chondrogenesis. Additionally, AGN-191659 effectively reverses fibroblast growth factor-induced endothelial cell proliferation and inhibits heparin-releasable lipase activity. This compound is valuable for research related to promyelocytic leukemia and hypertriglyceridemia.
AGN-191659 is a potent agonist of retinoid X receptors (RXR) and retinoic acid receptors (RAR), exhibiting EC50 values of 11 nM, 23 nM, and 37 nM for RXRα, RARβ, and RARγ, respectively. It enhances gene transcription through activation of these receptors and has demonstrated significant biological activities, including the induction of tissue transglutaminase and suppression of chondrogenesis. Additionally, AGN-191659 effectively reverses fibroblast growth factor-induced endothelial cell proliferation and inhibits heparin-releasable lipase activity. This compound is valuable for research related to promyelocytic leukemia and hypertriglyceridemia.
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