AGN 193109 sodium is a potent pan antagonist of retinoic acid receptors (RAR), specifically targeting RARα, RARβ, and RARγ with dissociation constants (Kd) of 2, 2, and 3 nM, respectively. This compound effectively reverses morphology changes induced by TTNPB and alleviates the proliferation suppression caused by all-trans retinoic acid, 9-cis RA, and 13-cis RA in ECE16-1 cells. Additionally, AGN 193109 sodium serves as an antidote for retinoic acidosis, mitigating skin and mucosal toxicity associated with retinoid treatment.
AGN 193109 sodium is a potent pan antagonist of retinoic acid receptors (RAR), specifically targeting RARα, RARβ, and RARγ with dissociation constants (Kd) of 2, 2, and 3 nM, respectively. This compound effectively reverses morphology changes induced by TTNPB and alleviates the proliferation suppression caused by all-trans retinoic acid, 9-cis RA, and 13-cis RA in ECE16-1 cells. Additionally, AGN 193109 sodium serves as an antidote for retinoic acidosis, mitigating skin and mucosal toxicity associated with retinoid treatment.
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