AhR Ligand-Linker Conjugates 1

Catalog No.: A80136
E3 Ligase Ligand-Linker Conjugates
AhR Ligand-Linker Conjugates 1 is designed as an E3 ubiquitin ligase ligand-linker conjugate that incorporates an IAP (inhibitor of apoptosis) ligand alongside a SNIPER (Specific and Pioneering IAP-medited Protein elimination) linker. This reagent enables the targeted degradation of specific proteins through the recruitment of E3 ligases. Its applications extend to drug discovery and the study of protein regulation through the ubiquitin-proteasome system, facilitating advancements in therapeutic strategies.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAhR Ligand-Linker Conjugates 1 is designed as an E3 ubiquitin ligase ligand-linker conjugate that incorporates an IAP (inhibitor of apoptosis) ligand alongside a SNIPER (Specific and Pioneering IAP-medited Protein elimination) linker. This reagent enables the targeted degradation of specific proteins through the recruitment of E3 ligases. Its applications extend to drug discovery and the study of protein regulation through the ubiquitin-proteasome system, facilitating advancements in therapeutic strategies.
Product Information
Catalog NumA80136
FormulaC26H27NO5
Molecular Weight433.50
CAS Number2380012-98-4
SMILESNCCOCCOCCOCC1=CC=C(C2=CC(C3=C(O2)C=CC4=CC=CC=C34)=O)C=C1
SynonymsE3 Ligase Ligand-Linker Conjugates 57
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