AK-068 is a high-affinity ligand for STAT6, exhibiting a binding affinity with a Ki of 6 nM. It shows remarkable selectivity, with over 150-fold preference for STAT6 compared to STAT5A and over 85-fold against STAT5B. This compound serves as a beneficial building block for the synthesis of PROTACs, allowing for targeted protein degradation research applications and potential therapeutic development.
AK-068 is a high-affinity ligand for STAT6, exhibiting a binding affinity with a Ki of 6 nM. It shows remarkable selectivity, with over 150-fold preference for STAT6 compared to STAT5A and over 85-fold against STAT5B. This compound serves as a beneficial building block for the synthesis of PROTACs, allowing for targeted protein degradation research applications and potential therapeutic development.
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