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Biological Activity
Alcaftadine is a high affinity ligand for the H1 receptor, with a pKi (8.5) that is comparable with that of other H1 antihistamines. Alcaftadine is also an antagonist for H2 and H4 receptors with no affinity for the H3 receptor.
In vitro | DMSO | 26 mg/mL (84.57 mM) | |
Water | Insoluble | ||
Ethanol | 57 mg/mL (185.43 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 32.53 mL | 162.66 mL | 325.32 mL |
0.5 mM | 6.51 mL | 32.53 mL | 65.06 mL |
1 mM | 3.25 mL | 16.27 mL | 32.53 mL |
5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
*The above data is based on the productmolecular weight 307.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A16393 |
---|---|
Actions | Antagonist |
CAS No. | 147084-10-4 |
Formula | C19H21N3O |
M. Wt | 307.39 |
Purity | >98% |
Synonyms | R89674, R 89674, R-89674 |
SMILES | CN1CC/C(CC1)=C2C3=CC=CC=C3CCN4C(C=O)=CN=C/24 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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