Alloc-Val-Ala-pAB is a peptide-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). The Val-Ala segment is selectively cleaved by the enzyme Cathepsin B, facilitating the targeted release of cytotoxic agents. The Alloc group exhibits stability under treatment with piperidine and TFA, yet can be efficiently removed under mild conditions through palladium-catalyzed allyl transfer, making it a versatile component for precise drug delivery applications.
Alloc-Val-Ala-pAB is a peptide-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). The Val-Ala segment is selectively cleaved by the enzyme Cathepsin B, facilitating the targeted release of cytotoxic agents. The Alloc group exhibits stability under treatment with piperidine and TFA, yet can be efficiently removed under mild conditions through palladium-catalyzed allyl transfer, making it a versatile component for precise drug delivery applications.
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