ADC Linker

Fmoc-Val-Cit-PAB is a cleavable linker for antibody-drug-conjugation (ADC).

2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a macrocycle DOTA derivative for tumor pretargeting.

Ozogamicin is an antibody-drug conjugate Linker.

PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).

Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE .

Fmoc-Val-Cit-PAB-PNP is a cleavable peptide linker, is a linker for antibody-drug-conjugation (ADC).

Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC peptide linker.

Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.

Mal-amido-PEG8-C2-acid (example 142) is a nonclaevable ADC linker, extracted from patent US2018339985.

MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker.

SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).

Vipivotide tetraxetan Linker (PSMA-617 Linker) is a nonclaevable peptide linker for synthesis of Vipivotide tetraxetan (PSMA-617).

SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses.

SPDB is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs).

DBCO-NHS ester 2 is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 2 is a derivative of Dibenzylcyclooctyne (DBCO) used in copper-free click chemistry.

Fmoc-Phe-Lys(Boc)-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Macropa-NCS is conjugated to trastuzumab as well as to the prostate-specific membrane antigen-targeting compound RPS-070. A promising therapeutic radionuclide applied in the treatment of soft-tissue metastases.

CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours).

L2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker.

EC089 is a cleavable linker used in conjugates of tubulysins and folates, and extracted from patent WO2011069116A1.

EC1167 is the linker for EC1169. EC1169 is prostate-specific membrane antigen targeting-tubulysin conjugate. EC1169 has the potential to treat recurrent metastatic, castration-resistant prostate cancer (MCRPC).

6-O-2-Propyn-1-yl-D-galactose is a nonclaevable glycolinker for the functionalization of cytotoxic drugs and applications in antibody-drug conjugation.

Fmoc-PEA (Example 1-2) is a used as a cleavable linker for antibody-drug conjugates (ADC).

SPP is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate.

AMAS is a nonclaevable heterobifunctional crosslinker with NHS ester and maleimide groups that allows covalent conjugation of amine- and sulfhydryl-containing molecules.

Biotin-PEG3-amineis PEG derivative containing a biotin group and a terminal primary amine group.

BS2G Crosslinker Disodium is an amine-reactive homobifunctional crosslinker that targets amine groups on proteins and peptides. This reagent facilitates the stable conjugation of proteins, peptides, and biomolecules, making it valuable in the development of antibody-drug conjugates (ADCs). Its application extends to various biochemical research and therapeutic studies, where precise linkage is essential for functionality.

Val-cit-PAB-OH is a cleavable ADC linker.

FBN33428, also known as Fmoc-Phe-?Lys(Boc)-PAB; is a Hydrolyzable linker for making ADC conjugate

Val-Lys(Boc)-PAB is a ADC linker.

MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC).

Boc-Gly-Gly-Phe-Gly-OH is a protease cleavable linker used for the antibody-drug conjugate (ADC).

Boc-Dap-NE is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Mc-Gly-Gly-Phe-Gly-PAB-OH (Mc-GGFG-PAB-OH) is a cleavable ADC linker used for antibody-drug conjugates (ADCs).

DBCO-NHS ester is a non-cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs). It serves as a click chemistry reagent, featuring a DBCO moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound is essential for bioconjugation applications, allowing for the stable attachment of therapeutics to antibodies, thereby enhancing the efficacy and specificity of targeted drug delivery in cancer research.

Sulfo-SMCC sodium is a hetero-bifunctional ADC linker that features both an N-hydroxysuccinimide (NHS) ester and a maleimide functional group. It facilitates efficient coupling by selectively reacting with primary amines and sulfhydryl groups, forming stable noncleavable linkages. This reagent is widely employed in the development of antibody-drug conjugates (ADCs), enabling targeted delivery of therapeutic agents for enhanced efficacy in cancer treatment and other diseases.

Desthiobiotin-Iodoacetamide functions primarily as an antibody-drug conjugate (ADC) linker, facilitating targeted drug delivery in therapeutic applications. It exhibits a strong affinity for biotin-binding proteins, making it useful in the labeling and detection of proteins in various biological assays. Additionally, this compound can be utilized as a probe for studying Oridonin-treated cell lysis, enhancing the understanding of cellular responses in drug treatment studies.

DOTA-NHS-ester is a labeling agent that facilitates the conjugation of affibody molecules for applications in molecular imaging. It is commonly utilized in small animal positron emission tomography (PET), single-photon emission computed tomography (SPECT), and computed tomography (CT). This reagent effectively labels radiotherapeutic agents or imaging probes, aiding in the detection and characterization of tumors.

15-Azido-pentadecanoic acid is an azide-containing compound widely utilized in click chemistry applications. This reagent is particularly effective for labeling and characterizing post-translationally palmitylated proteins through a straightforward two-step labeling process. Additionally, it can engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-functionalized molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, providing versatile approaches for conjugation in chemical biology research.

N-Hydroxysulfosuccinimide sodium serves as a non-cleavable linker for antibody-drug conjugates (ADCs). By enabling stable covalent attachment of cytotoxic drugs to antibodies, it plays a crucial role in enhancing targeted cancer therapy. This reagent is widely utilized in the development and optimization of ADC formulations for improved therapeutic efficacy.

Azido-PEG2-C2-amine is a PEG-based linker designed for use in PROTAC synthesis. This compound features an azide moiety that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, facilitating conjugation with alkyne-bearing molecules. Additionally, Azido-PEG2-C2-amine serves as a non-cleavable linker for the development of antibody-drug conjugates (ADCs), making it a versatile tool in chemical biology and drug discovery applications.

N3-PEG4-C2-NHS ester is a non-cleavable 4-unit polyethylene glycol (PEG) linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN functionalities. Due to its unique properties, N3-PEG4-C2-NHS ester is a valuable tool for the development of targeted therapeutics.

Maleimide-DOTA is a non-cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs). It facilitates stable attachment of therapeutic agents to antibodies, ensuring effective delivery to target cells while maintaining the drug's biological activity. This compound plays a crucial role in ADC development for targeted cancer therapies and related research applications.

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable linker designed for use in the synthesis of antibody-drug conjugates (ADCs). This linker facilitates the selective release of cytotoxic agents in targeted cancer therapies, enhancing therapeutic efficacy while minimizing off-target effects. Its structured design supports optimal stability and effective drug delivery, making it a valuable component in ADC research and development.

3-Azidopropylamine is a click chemistry reagent designed for efficient bioconjugation through its azide functional group. It facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and ring strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing molecules, including those with DBCO or BCN groups. This reagent is particularly useful in applications involving complexation and transfection of plasmid DNA, making it valuable for molecular biology and materials science research.

Fmoc-NH-PEG4-CH2CH2COOH is a cleavable linker designed for antibody-drug conjugates (ADCs), facilitating the targeted delivery of cytotoxic agents to cancer cells. This compound serves as a PEG-based PROTAC linker, enabling the construction of proteolysis-targeting chimeras (PROTACs) for efficient degradation of specific proteins in various biological contexts. It is suitable for applications in drug development and biochemical research, particularly in the fields of oncology and targeted therapeutics.

6-Azido-hexylamine is a versatile cleavable linker utilized in the development of antibody-drug conjugates (ADCs). It features an azide functional group that participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. This compound is essential for the precise attachment of cytotoxic agents to antibodies, facilitating targeted cancer therapies.

DBCO-PEG4-Maleimide is a non-cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. It is essential for applications in targeted drug delivery, enhancing the therapeutic efficacy of ADCs while minimizing off-target effects.

Mal-PEG4-NHS ester is a non-cleavable ADC linker that facilitates the conjugation of biomolecules, particularly linking Quantum dots (QDs) with PEGylated liposomes. This compound exhibits key biological activity by enhancing the stability and solubility of the assembled conjugates. It is primarily utilized in antibody-drug conjugate (ADC) development, nanomedicine, and for improving drug delivery systems in research applications.

DBCO-PEG5-NHS ester is a cleavable linker designed for use in antibody-drug conjugates (ADCs) and PROTAC synthesis. This PEG/alkyl/ether-based reagent facilitates the formation of stable covalent bonds through strain-promoted alkyne-azide cycloaddition (SPAAC), targeting azide-functionalized molecules. Its defined structure enhances the efficacy and specificity of therapeutic compounds, making it a valuable tool for researchers in the development of targeted therapies.