Almorexant HCl

Catalog No.: A14286

OX1/OX2 Antagonist

Almorexant HCl

Almorexant HCl Chemical Structure

CAS NO. 913358-93-7

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor 3.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$200.00
25 mg
$450.00
10mM * 1mL in DMSO
$145.00
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Biological Activity

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor 3.
Targets
OX2 receptor OX1 receptor
3.4 nM6.6 nM
In vitro (25°C) DMSO 62 mg/mL (112.93 mM)
Water Insoluble
Ethanol 44 mg/mL (80.14 mM)
In vivo 2% DMSO+25% ??-cyclodextrin in saline 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.21 mL 91.07 mL 182.14 mL
0.5 mM 3.64 mL 18.21 mL 36.43 mL
1 mM 1.82 mL 9.11 mL 18.21 mL
5 mM 0.36 mL 1.82 mL 3.64 mL

*The above data is based on the productmolecular weight 549.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14286
Actions Antagonist
CAS No. 913358-93-7
Formula C29H32ClF3N2O3
M. Wt 549.02
Purity >98%
SMILES CNC(=O)[[email protected]@H](C1=CC=CC=C1)N2CCC3=CC(=C(C=C3[[email protected]@H]2CCC4=CC=C(C=C4)C(F)(F)F)OC)OC.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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