Almorexant HCl

Catalog No.: A14286
OX1/OX2 Antagonist
Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor 3.
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Product Name Price Stock Qty
Almorexant HCl 5mg
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Almorexant HCl 10mg
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Almorexant HCl 25mg
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Almorexant HCl 10mM * 1mL in DMSO
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Adooq Products cited in reputable paper
Adooq's Almorexant HCl has been cited by 1 publications
  • Ryan J Keenan, .et al. , Br J Pharmacol, 2022, Jul;179(13):3403-3417 PMID: 35112344
  • Biological Activity
    Discription Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor 3.
    Target Value
    Product Information
    Catalog Num A14286
    Formula C29H32ClF3N2O3
    Molecular Weight 549.02
    CAS Number 913358-93-7
    SMILES CNC(=O)[C@@H](C1=CC=CC=C1)N2CCC3=CC(=C(C=C3[C@@H]2CCC4=CC=C(C=C4)C(F)(F)F)OC)OC.Cl

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro (25°C) DMSO 62 mg/mL (112.93 mM)
    Water Insoluble
    Ethanol 44 mg/mL (80.14 mM)
    In vivo 2% DMSO+25% ??-cyclodextrin in saline 8 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18.21 mL 91.07 mL 182.14 mL
    0.5 mM 3.64 mL 18.21 mL 36.43 mL
    1 mM 1.82 mL 9.11 mL 18.21 mL
    5 mM 0.36 mL 1.82 mL 3.64 mL
    Useful Calculator

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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