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Almorexant HCl

OX1/OX2 Antagonist

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Catalog No. A14286

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Almorexant HCl 5mg A14286-5
Almorexant HCl 10mg A14286-10
Almorexant HCl 25mg A14286-25
Almorexant HCl 10mM * 1mL in DMSO A14286-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor 3.

Almorexant HCl

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Chemical Information

Catalog Num A14286
Actions Antagonist
M. Wt 549.02
Formula C29H32ClF3N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 913358-93-7
Synonyms N/A
SMILES CNC(=O)[[email protected]@H](C1=CC=CC=C1)N2CCC3=CC(=C(C=C3[[email protected]@H]2CCC4=CC=C(C=C4)C(F)(F)F)OC)OC.Cl

Biological Activity

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor 3.
OX2 receptor OX1 receptor
3.4 nM6.6 nM


Solubility (25°C)* In vitro DMSO 72 mg/mL (131.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol 51 mg/mL (92.89 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.21 mL 91.07 mL 182.14mL
0.5 mM 3.64 mL 18.21 mL 36.43 mL
1 mM 1.82 mL 9.11 mL 18.21 mL
5 mM 0.36 mL 1.82 mL 3.64 mL

*The above data is based on the productmolecular weight 549.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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