ALRT1550 is a potent selective agonist of the retinoic acid receptors (RARs), exhibiting Kd values between 1-4 nM. This compound demonstrates significant anti-proliferative effects, evidenced by an IC50 of 0.22 nM in UMSCC-22B squamous carcinoma cells. In vivo studies in mouse tumor xenograft models have shown ALRT1550 to inhibit tumor growth in a dose-dependent manner, achieving up to 89% inhibition at maximum doses. This reagent is highly relevant for research focused on cancer biology and therapeutic applications targeting the retinoic acid signaling pathway.
ALRT1550 is a potent selective agonist of the retinoic acid receptors (RARs), exhibiting Kd values between 1-4 nM. This compound demonstrates significant anti-proliferative effects, evidenced by an IC50 of 0.22 nM in UMSCC-22B squamous carcinoma cells. In vivo studies in mouse tumor xenograft models have shown ALRT1550 to inhibit tumor growth in a dose-dependent manner, achieving up to 89% inhibition at maximum doses. This reagent is highly relevant for research focused on cancer biology and therapeutic applications targeting the retinoic acid signaling pathway.
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