ALV1 is a molecular glue degrader targeting Ikaros (IKZF1) and Helios (IKZF2), with degradation constants (DC50) of 2.5 nM and 10.3 nM, respectively. It interacts with cereblon (CRBN) with an IC50 of 0.55 μM, promoting CRBN-Helios dimerization. ALV1 is useful for investigating the roles and mechanisms of regulatory T cells in various biological contexts.
ALV1 is a molecular glue degrader targeting Ikaros (IKZF1) and Helios (IKZF2), with degradation constants (DC50) of 2.5 nM and 10.3 nM, respectively. It interacts with cereblon (CRBN) with an IC50 of 0.55 μM, promoting CRBN-Helios dimerization. ALV1 is useful for investigating the roles and mechanisms of regulatory T cells in various biological contexts.
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