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- Naoki Dohi, .et al. Quantitative real-time measurement of endothelin-1-induced contraction in single non-activated hepatic stellate cells, PLoS One, 2021, 16(8): e0255656 PMID: 34343209
- Tony Ngo, .et al. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors, Nat Chem Biol, 2017, Feb; 13(2): 235-242 PMID: 27992882
- Toshiaki Okamoto, .et al. Antifibrotic effects of ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model, World J Hepatol, 2016, Aug 8; 8(22): 933-941 PMID: 27574547
Biological Activity
Ambrisentan functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA).
Targets
| ET-A | ||||
| In vitro | DMSO | 72 mg/mL (190.26 mM) | |
| Water | Insoluble | ||
| Ethanol | 21 mg/mL (55.49 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.43 mL | 132.14 mL | 264.27 mL |
| 0.5 mM | 5.29 mL | 26.43 mL | 52.85 mL |
| 1 mM | 2.64 mL | 13.21 mL | 26.43 mL |
| 5 mM | 0.53 mL | 2.64 mL | 5.29 mL |
*The above data is based on the productmolecular weight 378.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11291 |
|---|---|
| Actions | Antagonist |
| CAS No. | 177036-94-1 |
| Formula | C22H22N2O4 |
| M. Wt | 378.4 |
| Purity | >98% |
| Synonyms | BSF 208075, |
| SMILES | CC1=CC(=NC(=N1)O[[email protected]](C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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