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Ambrisentan (BSF 208075)

Catalog No.: A11291

EndothelinA receptor antagonist

Ambrisentan (BSF 208075)

Ambrisentan (BSF 208075) Chemical Structure

CAS NO. 177036-94-1

Ambrisentan functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA).

Availability: In stock

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5 mg
10 mg
25 mg
50 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Naoki Dohi, .et al. Quantitative real-time measurement of endothelin-1-induced contraction in single non-activated hepatic stellate cells, PLoS One, 2021, 16(8): e0255656 PMID: 34343209
  • Tony Ngo, .et al. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors, Nat Chem Biol, 2017, Feb; 13(2): 235-242 PMID: 27992882
  • Toshiaki Okamoto, .et al. Antifibrotic effects of ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model, World J Hepatol, 2016, Aug 8; 8(22): 933-941 PMID: 27574547

Biological Activity

Ambrisentan functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA).
In vitro DMSO 72 mg/mL (190.26 mM)
Water Insoluble
Ethanol 21 mg/mL (55.49 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.43 mL 132.14 mL 264.27 mL
0.5 mM 5.29 mL 26.43 mL 52.85 mL
1 mM 2.64 mL 13.21 mL 26.43 mL
5 mM 0.53 mL 2.64 mL 5.29 mL

*The above data is based on the productmolecular weight 378.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11291
Actions Antagonist
CAS No. 177036-94-1
Formula C22H22N2O4
M. Wt 378.4
Purity >98%
Synonyms BSF 208075,
SMILES CC1=CC(=NC(=N1)O[[email protected]](C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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