AMG-126737 is a highly selective oral inhibitor of human mast cell tryptase, exhibiting a Ki value of 90 nM. This compound effectively suppresses both early and late-phase bronchoconstriction in sheep models. AMG-126737 is an important tool in the research of asthma and allergic diseases, enabling investigations into novel therapeutic strategies for these conditions.
AMG-126737 is a highly selective oral inhibitor of human mast cell tryptase, exhibiting a Ki value of 90 nM. This compound effectively suppresses both early and late-phase bronchoconstriction in sheep models. AMG-126737 is an important tool in the research of asthma and allergic diseases, enabling investigations into novel therapeutic strategies for these conditions.
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