AMG-510 (Sotorasib)

Catalog No.: A19021

KRAS G12C covalent inhibitor

AMG-510 (Sotorasib)

AMG-510 (Sotorasib) Chemical Structure

CAS NO. 2296729-00-3

AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$160.00
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Biological Activity

AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.
In vitro DMSO 90 mg/mL (160.54 mM)
Water Insoluble
Ethanol 90 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.84 mL 89.19 mL 178.38 mL
0.5 mM 3.57 mL 17.84 mL 35.68 mL
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL

*The above data is based on the productmolecular weight 560.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A19021
Actions Inhibitor
CAS No. 2296729-00-3
Formula C30H30F2N6O3
M. Wt 560.59
Solubility DMSO
Purity >98%
Synonyms AMG 510, AMG510, Sotorasib
SMILES O=C(C=C)N1C[[email protected]](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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