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Biological Activity
AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.
| In vitro | DMSO | 90 mg/mL (160.54 mM) | |
| Water | Insoluble | ||
| Ethanol | 90 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.84 mL | 89.19 mL | 178.38 mL |
| 0.5 mM | 3.57 mL | 17.84 mL | 35.68 mL |
| 1 mM | 1.78 mL | 8.92 mL | 17.84 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.57 mL |
*The above data is based on the productmolecular weight 560.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A19021 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2296729-00-3 |
| Formula | C30H30F2N6O3 |
| M. Wt | 560.59 |
| Purity | >98% |
| Synonyms | AMG 510, AMG510, Sotorasib |
| SMILES | O=C(C=C)N1C[[email protected]](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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