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- Veronica Rendo, .et al. Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy, Nat Commun, 2020, 11: 1308 PMID: 32161261
Biological Activity
Amonafide is a DNA intercalator and topoisomerase II inhibitor for the treatment of neoplastic diseases, one of Antitumor agent.
Targets
| Topo II | ||||
| In vitro | DMSO | 51 mg/mL (179.99 mM) | |
| Water | Insoluble | ||
| Ethanol | 4 mg/mL (14.11 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.3 mL | 176.49 mL | 352.98 mL |
| 0.5 mM | 7.06 mL | 35.3 mL | 70.6 mL |
| 1 mM | 3.53 mL | 17.65 mL | 35.3 mL |
| 5 mM | 0.71 mL | 3.53 mL | 7.06 mL |
*The above data is based on the productmolecular weight 283.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10071 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 69408-81-7 |
| Formula | C16H17N3O2 |
| M. Wt | 283.3 |
| Purity | >98% |
| Synonyms | AS1413, Xanafide, Quinamed |
| SMILES | CN(C)CCN1C(=O)C2=CC=CC3=CC(=CC(=C32)C1=O)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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