Crisaborole (AN2728)

Name: Crisaborole (AN2728)
SKU: A12776
Price: 32 USD
Rating: 5 (288 reviews)

Catalog No.: A12776

PDE4 inhibitor?€?

AN2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines

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Grouped product items
Product Name	Price	Stock
Crisaborole (AN2728) 10mg	Special Price $32.00 Regular Price $40.00	In stock
Crisaborole (AN2728) 50mg	Special Price $44.00 Regular Price $55.00	In stock
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Data Sheet

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Biological Activity

Discription	AN2728 is a topically administered, boron-containing, anti-inflammatory compound that inhibits PDE4 activity and thereby suppresses the release of TNFalpha, IL-12, IL-23 and other cytokines

Product Information

Catalog Num	A12776
Formula	C14H10BNO3
Molecular Weight	251.08
CAS Number	906673-24-3
SMILES	B1(C2=C(CO1)C=C(C=C2)OC3=CC=C(C=C3)C#N)O
Synonyms	AN 2728, AN-2728
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro	DMSO	47 mg/mL (187.21 mM)
	* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	39.83 mL	199.14 mL	398.28 mL
0.5 mM	7.97 mL	39.83 mL	79.66 mL
1 mM	3.98 mL	19.91 mL	39.83 mL
5 mM	0.8 mL	3.98 mL	7.97 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂