ANX-510

Catalog No.: A12370

ANX-510 Chemical Structure

CAS NO. 3432-99-3

ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity.

Availability: Out of stock

Package Price
5 mg

Regular Price: $180.00

Special Price $144.00

10 mg

Regular Price: $350.00

Special Price $280.00

25 mg

Regular Price: $600.00

Special Price $480.00

50 mg

Regular Price: $1,000.00

Special Price $800.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.86 mL 109.3 mL 218.61 mL
0.5 mM 4.37 mL 21.86 mL 43.72 mL
1 mM 2.19 mL 10.93 mL 21.86 mL
5 mM 0.44 mL 2.19 mL 4.37 mL

*The above data is based on the productmolecular weight 457.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12370
M. Wt 457.44
Formula C20H23N7O6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 3432-99-3
Synonyms ANX510; CoFactor; 5,10-methylenetetrahydrofolate; 5,10-Methylene-5,6,7,8-tetrahydrofolate; 5,10-MTHF; MTHF
SMILES C1C2CN(CN2C3=C(N1)NC(=NC3=O)N)C4=CC=C(C=C4)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)O

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