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- Chern Chiuh Woo,et al. Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma, Oncotarget, 2016, Aug 16; 7(33): 53005-53017 27391339
|Storage||at -20°C 3 years Powder|
|Synonyms||ANX510; CoFactor; 5,10-methylenetetrahydrofolate; 5,10-Methylene-5,6,7,8-tetrahydrofolate; 5,10-MTHF; MTHF|
|SMILES code||C1C2CN(CN2C3=C(N1)NC(=NC3=O)N)C4=CC=C(C=C4)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)O|
|Chemical Name||(2S)-2-(4-(3-amino-1-oxo-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(1H,4H,9H)-yl)benzamido)pentanedioic acid|
|ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity.|
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||21.86 mL||109.3 mL||218.61mL|
|0.5 mM||4.37 mL||21.86 mL||43.72 mL|
|1 mM||2.19 mL||10.93 mL||21.86 mL|
|5 mM||0.44 mL||2.19 mL||4.37 mL|
*The above data is based on the productmolecular weight 457.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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