AP14145 is a selective inhibitor of small conductance calcium-activated potassium channels, specifically targeting KCa2.2 and KCa channels with an IC50 of 1.1 μM. This compound has demonstrated the ability to prolong the atrial effective refractory period (AERP) in rat models and facilitate the conversion of atrial fibrillation to sinus rhythm in porcine models of left ventricular dysfunction. Its antiarrhythmic properties make AP14145 a valuable tool in cardiac electrophysiology research and the study of arrhythmias.
AP14145 is a selective inhibitor of small conductance calcium-activated potassium channels, specifically targeting KCa2.2 and KCa channels with an IC50 of 1.1 μM. This compound has demonstrated the ability to prolong the atrial effective refractory period (AERP) in rat models and facilitate the conversion of atrial fibrillation to sinus rhythm in porcine models of left ventricular dysfunction. Its antiarrhythmic properties make AP14145 a valuable tool in cardiac electrophysiology research and the study of arrhythmias.
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