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APL-1081

Catalog No.: A41405
Drug-Linker Conjugates for ADC
APL-1081 is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). It features the Mal-Exo-EEVC peptide linker that facilitates effective targeting and delivery, combined with the potent tubulin polymerization inhibitor MMAE. This compound demonstrates significant biological activity by disrupting microtubule dynamics, making it valuable for research focused on cancer therapeutics and ADC development.
APL-1081 2921735-80-8 Drug-Linker Conjugates for ADC
Grouped product items
Size Price Stock Qty
1mg
$410.00
In stock
5mg
$1,005.00
In stock
10mg
$1,650.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAPL-1081 is a drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). It features the Mal-Exo-EEVC peptide linker that facilitates effective targeting and delivery, combined with the potent tubulin polymerization inhibitor MMAE. This compound demonstrates significant biological activity by disrupting microtubule dynamics, making it valuable for research focused on cancer therapeutics and ADC development.
Product Information
Catalog NumA41405
FormulaC75H115N13O19
Molecular Weight1502.79
CAS Number2921735-80-8
SMILESO[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OC(C3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)C(NCCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)OC)=O
SynonymsMal-Exo-EVC-MMAE
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC