APP degrader-1 is an orally active compound designed to target the amyloid precursor protein (APP). It induces the degradation of APP and effectively reduces the extracellular release of Aβ42. By binding to both CAPRIN1 and APP, APP degrader-1 enhances their interaction and facilitates CAPRIN1-mediated APP degradation via the endosome-lysosome pathway. This compound holds potential for research applications related to Alzheimer's disease and protein misfolding disorders.
APP degrader-1 is an orally active compound designed to target the amyloid precursor protein (APP). It induces the degradation of APP and effectively reduces the extracellular release of Aβ42. By binding to both CAPRIN1 and APP, APP degrader-1 enhances their interaction and facilitates CAPRIN1-mediated APP degradation via the endosome-lysosome pathway. This compound holds potential for research applications related to Alzheimer's disease and protein misfolding disorders.
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