Aprocitentan

Catalog No.: A21999
dual ETA/ETB antagonist
Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively.
Grouped product items
Size Price Stock Qty
1mg
$45.00
In stock
5mg
$110.00
In stock
10mg
$170.00
In stock
25mg
$320.00
In stock
50mg
$455.00
In stock
100mg
$685.00
In stock
200mg
$925.00
In stock
10mM * 1mL in DMSO
$140.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Biological Activity
Discription Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively.
Targets
Target Value
Cell Research
Cell Line Type Value Description References
Product Information
Catalog Num A21999
Formula C16H14Br2N6O4S
Molecular Weight 546.19
CAS Number 1103522-45-7
SMILES O=S(N)(NC1=NC=NC(OCCOC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O
Synonyms ACT-132577,ACT132577, ACT 132577
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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