Aprocitentan

Catalog No.: A21999

dual ETA/ETB antagonist

Aprocitentan

Aprocitentan Chemical Structure

CAS NO. 1103522-45-7

Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively.

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Package Price Qty
5 mg
$378.00
10 mg
$651.00
50 mg
$1,932.00
100 mg
$3,864.00
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Biological Activity

Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of Macitentan. Aprocitentan is dual ETA/ETB antagonist with IC50s of 3.4 nM and 987 nM, and pA2 valus of 6.7 and 5.5, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.31 mL 91.54 mL 183.09 mL
0.5 mM 3.66 mL 18.31 mL 36.62 mL
1 mM 1.83 mL 9.15 mL 18.31 mL
5 mM 0.37 mL 1.83 mL 3.66 mL

*The above data is based on the productmolecular weight 546.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21999
Actions Antagonist
M. Wt 546.19
Formula C16H14Br2N6O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1103522-45-7
Synonyms ACT-132577,ACT132577, ACT 132577
SMILES O=S(N)(NC1=NC=NC(OCCOC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O

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