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APS-2-79 HCl, small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2).
Targets
| KSR2 | ||||
| 120 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.59 mL | 117.96 mL | 235.91 mL |
| 0.5 mM | 4.72 mL | 23.59 mL | 47.18 mL |
| 1 mM | 2.36 mL | 11.8 mL | 23.59 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.72 mL |
*The above data is based on the productmolecular weight 423.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16175 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 423.89 |
| Formula | C23H21N3O3.HCl |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 2002381-31-7 |
| Synonyms | KSR/Ras Inhibitor |
| SMILES | CC1=C(C=CC(=C1)OC2=CC=CC=C2)NC3=NC=NC4=CC(=C(C=C43)OC)OC.Cl |
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