APS-2-79 HCl

Catalog No.: A16175

KSR/Ras inhibitor

APS-2-79 HCl

APS-2-79 HCl Chemical Structure

CAS NO. 2002381-31-7

APS-2-79 HCl, small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2).

Availability: In stock

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5 mg

Regular Price: $45.00

Special Price $36.00

10 mg

Regular Price: $65.00

Special Price $52.00

50 mg

Regular Price: $210.00

Special Price $168.00

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Biological Activity

APS-2-79 HCl, small molecule that stabilizes the KSR (Kinase suppressor of Ras) inactive state and antagonizes oncogenic Ras signalling (IC50 value 120 nM against ATP-biotin probe-labelling of KSR2).
Targets
KSR2
120 nM
In vitro DMSO 82 mg/mL (193.44 mM)
Water Insoluble
Ethanol 27 mg/mL (63.69 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.59 mL 117.96 mL 235.91 mL
0.5 mM 4.72 mL 23.59 mL 47.18 mL
1 mM 2.36 mL 11.8 mL 23.59 mL
5 mM 0.47 mL 2.36 mL 4.72 mL

*The above data is based on the productmolecular weight 423.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16175
Actions Inhibitor
CAS No. 2002381-31-7
Formula C23H21N3O3.HCl
M. Wt 423.89
Purity >98%
Synonyms KSR/Ras Inhibitor
SMILES CC1=C(C=CC(=C1)OC2=CC=CC=C2)NC3=NC=NC4=CC(=C(C=C43)OC)OC.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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